Alkyl Halides
Medchemexpress LLC Spi-112 | 1051387-90-6 | MFCD31620831 | 98.0% | 468.46 g/mol | C22H17FN4O5S | 1 ML
SPI-112 is a potent, selective, and competitive inhibitor of SHP2 (PTPN11) used for in vitro biochemical and biophysical studies. It inhibits SHP2 with an IC50 of approximately 1 μM, with weaker activity against related phosphatases. Kinetic and binding data indicate competitive inhibition (Ki ≈ 0.8 μM) and 1:1 binding by SPR (KD ≈ 1.3 μM). The compound is not cell permeable and is supplied for research applications.
- Inhibits SHP2 with IC50 ≈ 1 μM.
- Shows selectivity over related phosphatases (IC50s 18.3 μM for PTP, 14.5 μM for PTP1B).
- Exhibits competitive inhibition kinetics (Ki ≈ 0.8 μM).
- Binds 1:1 in SPR with KD ≈ 1.3 μM.
- Not cell permeable due to polar or charged functional groups.
- Supplied as a solid and as a 10 mM solution for in vitro assays.
- High purity suitable for biochemical assays (≈98%).
- Store solid at 4°C; in solvent store at -80°C (long term) or -20°C (short term).
eMolecules ChemScene / 4-Chloro-N-hydroxybenzamide / 100mg / 714103995 / CS-0145140 / 0.000 / 1613-88-3 / MFCD03551074 / 171.580 / C7H6ClNO2
ChemScene / 4-Chloro-N-hydroxybenzamide / 100mg / 714103995 / CS-0145140 / 0.000 / 1613-88-3 / MFCD03551074 / 171.580 / C7H6ClNO2
eMolecules ChemScene / 2-(2-(Benzyloxy)phenyl)acetic acid / 250mg / 632297018 / CS-0156164 / 0.000 / 22047-88-7 / MFCD00016822 / 242.274 / C15H14O3
ChemScene / 2-(2-(Benzyloxy)phenyl)acetic acid / 250mg / 632297018 / CS-0156164 / 0.000 / 22047-88-7 / MFCD00016822 / 242.274 / C15H14O3
Matrix Scientific 5-BROMOVALERONITRILE-5G
5-Bromovaleronitrile, 98%; 5g,C5H8BrN, MFCD00001976, mw 162.04, [5414-21-1]
eMolecules 1-(2-Bromoethoxy)-3-chlorobenzene | 6487-84-9 | MFCD02030630 | 1g
Matrix Scientific | 1-(2-Bromoethoxy)-3-chlorobenzene | 1g | 389718059 | 16395 | 95.000 | 6487-84-9 | MFCD02030630 | 235.510 | C8H8BrClO
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Medchemexpress LLC hsa-miR-122-5p mimic 20nmol | 20nmol
hsa-miR-122-5p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity